He covered the St. Louis Cardinals on the radio alongside Harry Caray in the 1950s, then moved to the Chicago White Sox in the 1960s, backing up Bob Elson. He became a independent play-by-play human for the Atlanta Braves, and get on hand to famously call for Henry Aaron's record-breaking 715th career home rerun around 1974. He so returned to Chicago and covered the Chicago Cubs on TV for several years. He was under a impression that he was heir-apparent to Jack Brickhouse upon the latter's retirement, however Harry Caray was brought inside instead, & Hamilton afterward left a Cubs. He shortly joined higher sustaining a Houston Astros, and hwhen been their independent announcer ever since, however on the crew as of 2005. In July 29, 2005, Hamilton announced that starting using a 2006 year, he would there are no protracted accompany a club on tour, announcing merely front yard games.

Hamilton's style can be described when enthusiastic but not "over the top". His voice reminds the bit of of a Big Band-era announcer, crisp & clear, and real life on the ears.

He is besides known for his residence begin call for "Holy Toledo!" however his coverage of Aaron's record breaker was the little different. This is taken directly from either the track of ''Baseball's Greatest Hits: Let's Play II'':

Hamilton was a 1992 recipient of the Baseball Hall of Fame's Ford C. Frick Award. He has already been inducted into a National Radio Hall of Fame & shortly he is inducted into a Texas Radio Hall of Fame. His married woman of about 53 years, Arlene, passed away at age 73 inside February 2005. It keep close at h& 2 toddlers: Mark and Patricia.